Tetracycline이 백서의 경골 및 하악골발육에 미치는 영향에 관한 실험적 연구
EXPERIMENTAL STUDIES OF THE EFFECT OF TETRACYCLINE ON GROWTH OF TIBIA AND MANDIBLE IN RATS
이미대,
소속 상세정보
이미대 ( Lee Mi-Dae ) - 서울대학교 대학원 치의학과 교정학
KMID : 0361919750050010033
Abstract
To study the effect of the tetracycline-HCl on the growth of the rats, the author made a daily injection of tetracycline-HCl in the amount of 40mg/kg of body weight to the lactating mother and weanling rats for 7 days. Lactating and weanling young rats were killed at a week intervals and removed tibia and mandible from soft tissues. The effect of the tetracycline on the growth of rats were analysed from the weight, the length of tibia and the size of mandible. The results were as follows: 1. Tetracycline inhibited the growth of young rats. 2. Inhibitory effects were greater ill the weanling group than the lactating group. 3. The inhibitory effect was marked just after the injection of tetracycline-HCl in body weight and after a week in mandible and tibia. 4. The inhibitory effect of growth nab continued for 2-3 weeks in body weight and 3-4 weeks in tibia and mandible. 5. In growth of mandible, the antero-posterior growth was more inhibited than the vertical.
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